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Issue 33, 2019
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The influence of curvature on domain distribution in binary mixture membranes

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Abstract

Curvature-induced domain sorting, a strategy exploited by cells to organize membrane components, is a promising mechanism to control self-assembly of materials. To understand this phenomenon, this work explores the effects of curvature on component rearrangement in thin polymer films and lipid bilayers supported on sinusoidal substrates. Specifically, self-consistent field theory (SCFT) was used to study the spatial distribution of polymers in blends containing conformationally asymmetric chains. In addition, coarse-grained molecular dynamics (MD) simulations were used to probe the arrangement of rigid lipid domains in a relatively soft lipid matrix. Besides the expected preference of rigid species localizing in regions with low mean curvature, both systems exhibit unexpected localization of rigid components in comparatively high curvature regions. The origins of this unexpected sorting are discussed in terms of entropic and enthalpic contributions. In summary, this study demonstrates that domain distribution strongly depends on local topography and further highlights the collective effects that thermodynamic forces have on the morphological behavior of membranes.

Graphical abstract: The influence of curvature on domain distribution in binary mixture membranes

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Supplementary files

Article information


Submitted
24 Jun 2019
Accepted
10 Jul 2019
First published
12 Jul 2019

Soft Matter, 2019,15, 6642-6649
Article type
Paper
Author version available

The influence of curvature on domain distribution in binary mixture membranes

W. Li, J. Y. Carrillo, J. Katsaras, B. G. Sumpter, R. Ashkar and R. Kumar, Soft Matter, 2019, 15, 6642
DOI: 10.1039/C9SM01262A

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