Jump to main content
Jump to site search

Issue 29, 2019
Previous Article Next Article

Microrheological characterization of covalent adaptable hydrogels for applications in oral delivery

Author affiliations

Abstract

The feasibility of a covalent adaptable hydrogel (CAH) as an oral delivery platform is explored using μ2rheology, microrheology in a microfluidic device. CAH degradation is initiated by physiologically relevant pHs, including incubation at a single pH and consecutively at different pHs. At a single pH, we determine CAH degradation can be tuned by changing the pH, which can be exploited for controlled release. We calculate the critical relaxation exponent, which defines the gel–sol transition and is independent of the degradation pH. We mimic the changing pH environment through part of the gastrointestinal tract (pH 4.3 to 7.4 or pH 7.4 to 4.3) in our microfluidic device. We determine that dynamic material property evolution is consistent with degradation at a single pH. However, the time scale of degradation is reduced by the history of degradation. These investigations inform the design of this material as a new vehicle for targeted delivery.

Graphical abstract: Microrheological characterization of covalent adaptable hydrogels for applications in oral delivery

Back to tab navigation

Supplementary files

Publication details

The article was received on 08 Apr 2019, accepted on 29 Jun 2019 and first published on 01 Jul 2019


Article type: Paper
DOI: 10.1039/C9SM00714H
Soft Matter, 2019,15, 5921-5932

  •   Request permissions

    Microrheological characterization of covalent adaptable hydrogels for applications in oral delivery

    N. Wu and K. M. Schultz, Soft Matter, 2019, 15, 5921
    DOI: 10.1039/C9SM00714H

Search articles by author

Spotlight

Advertisements