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Conformationally directed assembly of peptides on 2D surfaces mediated by thermal stimuli

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Abstract

Dynamic and environmentally directed assembly of molecules in biological systems is essential for the fabrication of micronscale, hierarchical, functional structures. Here, we demonstrate the directed assembly of genetically selected graphite binding peptides on 2D solid surfaces upon thermal stimuli. Structural and kinetic analyses as well as molecular dynamics simulations yield the self-assembly process as thermally controllable upon tuning the solvated peptide conformational states. The ability to tailor the structure of two-dimensional soft bio/nano interfaces via external stimuli shows the potential for the bottom-up fabrication of complex materials with nanotechnological importance, such as biosensors, bioelectronics, and biomolecular fuel cells.

Graphical abstract: Conformationally directed assembly of peptides on 2D surfaces mediated by thermal stimuli

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Publication details

The article was received on 27 Feb 2019, accepted on 22 Jul 2019 and first published on 23 Jul 2019


Article type: Paper
DOI: 10.1039/C9SM00426B
Soft Matter, 2019, Advance Article

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    Conformationally directed assembly of peptides on 2D surfaces mediated by thermal stimuli

    T. D. Jorgenson, M. Milligan, M. Sarikaya and R. M. Overney, Soft Matter, 2019, Advance Article , DOI: 10.1039/C9SM00426B

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