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Destabilizing effect of perfluorodecanoic acid on simple membrane models

Abstract

Perfluoroalkyl acids (PFA) are amphiphilic surfactants widely used in industry with several commercial applications. An important feature of these compounds is their non-biodegradability and the tendency to bio-accumulate in the environment, which made these compounds to be considered among the most persistent pollutants worldwide. Many articles evidence their toxic effect on humans and wildlife. For this reason, more and more efforts have been made to better understand the effect of these compounds on living organisms. The aim of the present study is to understand how electrostatic interactions and film compactness of biological membranes models modulate their interaction with PFA, more specifically with perfluorodecanoic acid (PFD). Langmuir isotherms and Brewster angle microscopy (BAM) are used to evaluate the effect of PFD on lipid membrane models (air/water monolayers and vesicles) analyzing the behavior of PFD:lipid mixtures. The lipids used in this study are distearoyl phosphatidic acid (DSPA), dilauroyl phosphatidic acid (DLPA) and distearoyl phosphatidylethanolamine (DSPE). PFD induces an increase in the mean molecular area per lipid in monolayers, mainly at lower surface pressures. BAM images demonstrate that PFD mixes with DLPA, inducing a decrease in gray level, while it forms a non-miscible mixture with DSPA segregating PFD domains. Insertion studies of PFD within monolayers and dynamic light scattering experiments demonstrate that PFD can penetrate into monolayers and bilayers above 30 mNm-1, which is the lateral pressure value accepted for cellular bilayer.

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Publication details

The article was received on 10 Nov 2018, accepted on 30 Jan 2019 and first published on 31 Jan 2019


Article type: Paper
DOI: 10.1039/C8SM02301H
Citation: Soft Matter, 2019, Accepted Manuscript

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    Destabilizing effect of perfluorodecanoic acid on simple membrane models

    B. Viada, C. I. Cámara and L. M. Yudi, Soft Matter, 2019, Accepted Manuscript , DOI: 10.1039/C8SM02301H

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