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Issue 9, 2019
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Structure of lateral heterogeneities in a coarse-grained model for multicomponent membranes

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Abstract

We study the lateral domain structure in a coarse-grained molecular model for multicomponent lipid bilayers by semi-grandcanonical Monte Carlo simulations. The membranes are filled with liquid ordered (lo) domains surrounded by a liquid disordered (ld) matrix. Depending on the membrane composition and temperature, we identify different morphological regimes: one regime (I) where the lo domains are small and relatively compact, and two regimes (II, II′) where they are larger and often interconnected. In the latter two regimes, the ld matrix forms a network of disordered trenches separating the lo domains, with a relatively high content of interdigitated line defects. Since such defects are also a structural element of the modulated ripple phase in one component membranes, we argue that the regimes II, II′ may be amorphous equivalents of the ripple phase in multicomponent membranes. We also analyze the local structure and provide evidence that the domains in regime I are stabilized by a monolayer curvature mechanism postulated in earlier work [S. Meinhardt et al., PNAS, 2013, 110, 4476].

Graphical abstract: Structure of lateral heterogeneities in a coarse-grained model for multicomponent membranes

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Publication details

The article was received on 05 Nov 2018, accepted on 05 Jan 2019 and first published on 07 Jan 2019


Article type: Paper
DOI: 10.1039/C8SM02261E
Citation: Soft Matter, 2019,15, 1942-1952

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    Structure of lateral heterogeneities in a coarse-grained model for multicomponent membranes

    S. Meinhardt and F. Schmid, Soft Matter, 2019, 15, 1942
    DOI: 10.1039/C8SM02261E

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