Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 27th March 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.

Issue 6, 2019
Previous Article Next Article

Microfluidic fabrication of vesicles with hybrid lipid/nanoparticle bilayer membranes

Author affiliations


Hybrid lipid/nanoparticle membranes are suitable model systems both to study the complex interactions between nanoparticles and biological membranes, and to demonstrate technological concepts in cellular sensing and drug delivery. Unfortunately, embedding nanoparticles into the bilayer membrane of lipid vesicles is challenging due to the poor control over the vesicle fabrication process of conventional methodologies and the fragility of the modified lipid bilayer assembly. Here, the utility of water-in-oil-in-water double emulsion drops with ultrathin oil shells as templates to form vesicles with hybrid lipid/nanoparticle membranes is reported. Moreover, upon bilayer formation, which occurs through dewetting of the oil solvent from the double emulsion drops, a phase separation is observed in the vesicle membrane, with solid-like nanoparticle-rich microdomains segregated into a continuous fluid-like nanoparticle-poor phase. This phase coexistence evidences the complex nature of the interactions between nanoparticles and lipid membranes. In this context, this microfluidic-assisted fabrication strategy may play a crucial role in thoroughly understanding such interactions given the uniform membrane properties of the resulting productions. Furthermore, the high encapsulation efficiency of both the vesicle membrane and core endows these vesicles with great potential for sensing applications and drug delivery.

Graphical abstract: Microfluidic fabrication of vesicles with hybrid lipid/nanoparticle bilayer membranes

Back to tab navigation

Publication details

The article was received on 08 Oct 2018, accepted on 21 Dec 2018 and first published on 10 Jan 2019

Article type: Paper
DOI: 10.1039/C8SM02050G
Citation: Soft Matter, 2019,15, 1388-1395

  •   Request permissions

    Microfluidic fabrication of vesicles with hybrid lipid/nanoparticle bilayer membranes

    J. Perrotton, R. Ahijado-Guzmán, L. H. Moleiro, B. Tinao, A. Guerrero-Martinez, E. Amstad, F. Monroy and L. R. Arriaga, Soft Matter, 2019, 15, 1388
    DOI: 10.1039/C8SM02050G

Search articles by author