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Issue 20, 2019
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A cellular automaton for modeling non-trivial biomembrane ruptures

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Abstract

A novel cellular automaton (CA) for simulating biological membrane rupture is proposed. Constructed via simple rules governing deformation, tension, and fracture, the CA incorporates ideas from standard percolation models and bond-based fracture methods. The model is demonstrated by comparing simulations with experimental results of a double bilayer lipid membrane expanding on a solid substrate. Results indicate that the CA can capture non-trivial rupture morphologies such as floral patterns and the saltatory dynamics of fractal avalanches observed in experiments. Moreover, the CA provides insight into the poorly understood role of inter-layer adhesion, supporting the hypothesis that the density of adhesion sites governs rupture morphology.

Graphical abstract: A cellular automaton for modeling non-trivial biomembrane ruptures

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Supplementary files

Article information


Submitted
05 Oct 2018
Accepted
27 Apr 2019
First published
30 Apr 2019

Soft Matter, 2019,15, 4178-4186
Article type
Paper

A cellular automaton for modeling non-trivial biomembrane ruptures

A. Gupta, I. Gözen and M. Taylor, Soft Matter, 2019, 15, 4178
DOI: 10.1039/C8SM02032A

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