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Issue 3, 2019
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pH-Induced reorientation of cytochrome c on silica nanoparticles

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Abstract

The orientation of cytochrome c molecules at the surface of silica nanoparticles was studied in a wide pH range by combining small-angle neutron scattering, adsorption measurements, and molecular dynamics simulations. The results indicate a reorientation of the ellipsoidal protein from head-on to side-on as the pH is increased. This is attributed to changes in the surface charge distribution of both the protein and the nanoparticles.

Graphical abstract: pH-Induced reorientation of cytochrome c on silica nanoparticles

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Publication details

The article was received on 18 Sep 2018, accepted on 16 Nov 2018 and first published on 16 Nov 2018


Article type: Communication
DOI: 10.1039/C8SM01909F
Citation: Soft Matter, 2019,15, 350-354

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    pH-Induced reorientation of cytochrome c on silica nanoparticles

    J. Meissner, Y. Wu, J. Jestin, W. A. Shelton, G. H. Findenegg and B. Bharti, Soft Matter, 2019, 15, 350
    DOI: 10.1039/C8SM01909F

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