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Issue 45, 2019
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Hydration of nitriles using a metal–ligand cooperative ruthenium pincer catalyst

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Abstract

Nitrile hydration provides access to amides that are important structural elements in organic chemistry. Here we report catalytic nitrile hydration using ruthenium catalysts based on a pincer scaffold with a dearomatized pyridine backbone. These complexes catalyze the nucleophilic addition of H2O to a wide variety of aliphatic and (hetero)aromatic nitriles in tBuOH as solvent. Reactions occur under mild conditions (room temperature) in the absence of additives. A mechanism for nitrile hydration is proposed that is initiated by metal–ligand cooperative binding of the nitrile.

Graphical abstract: Hydration of nitriles using a metal–ligand cooperative ruthenium pincer catalyst

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Supplementary files

Article information


Submitted
13 Sep 2019
Accepted
04 Oct 2019
First published
07 Oct 2019

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2019,10, 10647-10652
Article type
Edge Article

Hydration of nitriles using a metal–ligand cooperative ruthenium pincer catalyst

B. Guo, J. G. de Vries and E. Otten, Chem. Sci., 2019, 10, 10647
DOI: 10.1039/C9SC04624K

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