Jump to main content
Jump to site search


Hydration of nitriles using a metal–ligand cooperative ruthenium pincer catalyst

Author affiliations

Abstract

Nitrile hydration provides access to amides that are important structural elements in organic chemistry. Here we report catalytic nitrile hydration using ruthenium catalysts based on a pincer scaffold with a dearomatized pyridine backbone. These complexes catalyze the nucleophilic addition of H2O to a wide variety of aliphatic and (hetero)aromatic nitriles in tBuOH as solvent. Reactions occur under mild conditions (room temperature) in the absence of additives. A mechanism for nitrile hydration is proposed that is initiated by metal–ligand cooperative binding of the nitrile.

Graphical abstract: Hydration of nitriles using a metal–ligand cooperative ruthenium pincer catalyst

Back to tab navigation

Supplementary files

Publication details

The article was received on 13 Sep 2019, accepted on 04 Oct 2019 and first published on 07 Oct 2019


Article type: Edge Article
DOI: 10.1039/C9SC04624K
Chem. Sci., 2019, Advance Article
  • Open access: Creative Commons BY-NC license
    All publication charges for this article have been paid for by the Royal Society of Chemistry

  •   Request permissions

    Hydration of nitriles using a metal–ligand cooperative ruthenium pincer catalyst

    B. Guo, J. G. de Vries and E. Otten, Chem. Sci., 2019, Advance Article , DOI: 10.1039/C9SC04624K

    This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material and it is not used for commercial purposes.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements