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Ni-catalyzed 1,2-benzylboration of 1,2-disubstituted unactivated alkenes

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Abstract

Nickel-catalyzed 1,2-carboboration of alkenes is emerging as a useful method for chemical synthesis. Prior studies have been limited to only the incorporation of aryl groups. In this manuscript, a method for the 1,2-benzylboration of unactivated alkenes is presented. The reaction combines readily available alkenes, diboron reagents and benzylchlorides to generate synthetically versatile products with control of stereochemistry. The utility of the products as well as the mechanistic details of the process are also presented.

Graphical abstract: Ni-catalyzed 1,2-benzylboration of 1,2-disubstituted unactivated alkenes

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Publication details

The article was received on 21 Aug 2019, accepted on 14 Oct 2019 and first published on 22 Oct 2019


Article type: Edge Article
DOI: 10.1039/C9SC04199K
Chem. Sci., 2019, Advance Article
  • Open access: Creative Commons BY-NC license
    All publication charges for this article have been paid for by the Royal Society of Chemistry

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    Ni-catalyzed 1,2-benzylboration of 1,2-disubstituted unactivated alkenes

    S. Joung, A. M. Bergmann and M. K. Brown, Chem. Sci., 2019, Advance Article , DOI: 10.1039/C9SC04199K

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