Jump to main content
Jump to site search


Enantioselective construction of the tricyclic core of curcusones A–D via a cross-electrophile coupling approach

Author affiliations

Abstract

Herein we report our recent progress toward the enantioselective total synthesis of the diterpenoid natural products curcusones A–D by means of complementary Stetter annulation or ring-closing metathesis (RCM) disconnections. Using the latter approach, we have achieved the concise construction of the 5–7–6 carbocyclic core embedded in each member of the curcusone family. Essential to this route is the use of a cross-electrophile coupling strategy, which has not previously been harnessed in the context of natural product synthesis.

Graphical abstract: Enantioselective construction of the tricyclic core of curcusones A–D via a cross-electrophile coupling approach

Back to tab navigation

Supplementary files

Publication details

The article was received on 16 Aug 2019, accepted on 30 Sep 2019 and first published on 01 Oct 2019


Article type: Edge Article
DOI: 10.1039/C9SC04127C
Chem. Sci., 2019, Advance Article
  • Open access: Creative Commons BY-NC license
    All publication charges for this article have been paid for by the Royal Society of Chemistry

  •   Request permissions

    Enantioselective construction of the tricyclic core of curcusones A–D via a cross-electrophile coupling approach

    A. C. Wright and B. M. Stoltz, Chem. Sci., 2019, Advance Article , DOI: 10.1039/C9SC04127C

    This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material and it is not used for commercial purposes.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements