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Enantioselective carbene insertion into the N–H bond of benzophenone imine

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Abstract

Efficient enantioselective insertion of α-diazoesters into the N–H bond of N-sp2-hybridized benzophenone imine was realized by using Rh2(esp)2 and chiral guanidine cooperative catalysis. Both aliphatic and aromatic substituted α-amino esters were obtained in high yields (up to 99%) and good enantioselectivities (up to 95.5 : 4.5 er) under mild reaction conditions.

Graphical abstract: Enantioselective carbene insertion into the N–H bond of benzophenone imine

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Publication details

The article was received on 08 Jul 2019, accepted on 16 Sep 2019 and first published on 18 Sep 2019


Article type: Edge Article
DOI: 10.1039/C9SC03354H
Chem. Sci., 2019, Advance Article
  • Open access: Creative Commons BY-NC license
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    Enantioselective carbene insertion into the N–H bond of benzophenone imine

    J. Yang, P. Ruan, W. Yang, X. Feng and X. Liu, Chem. Sci., 2019, Advance Article , DOI: 10.1039/C9SC03354H

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