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Canonical DNA minor groove insertion of bisbenzamidine–Ru(II) complexes with chiral selectivity

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Abstract

We report the first Ru(II) coordination compounds that interact with DNA through a canonical minor groove insertion mode and with selectivity for A/T rich sites. This was made possible by integrating a bis-benzamidine minor groove DNA-binding agent with a ruthenium(II) complex. Importantly, one of the enantiomers (Δ-[Ru(bpy)2b4bpy]2+, Δ-4Ru) shows a considerably higher DNA affinity than the parent organic ligand and the other enantiomer, particularly for the AATT sequence, while the other enantiomer preferentially targets long AAATTT sites with overall lower affinity. Finally, we demonstrate that the photophysical properties of these new binders can be exploited for DNA cleavage using visible light.

Graphical abstract: Canonical DNA minor groove insertion of bisbenzamidine–Ru(ii) complexes with chiral selectivity

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Publication details

The article was received on 20 Jun 2019, accepted on 30 Jul 2019 and first published on 01 Aug 2019


Article type: Edge Article
DOI: 10.1039/C9SC03053K
Chem. Sci., 2019, Advance Article
  • Open access: Creative Commons BY-NC license
    All publication charges for this article have been paid for by the Royal Society of Chemistry

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    Canonical DNA minor groove insertion of bisbenzamidine–Ru(II) complexes with chiral selectivity

    M. I. Sánchez, G. Rama, R. Calo-Lapido, K. Ucar, P. Lincoln, M. V. López, M. Melle-Franco, J. L. Mascareñas and M. E. Vázquez, Chem. Sci., 2019, Advance Article , DOI: 10.1039/C9SC03053K

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