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Interaction of single- and double-stranded DNA with multilayer MXene by fluorescence spectroscopy and molecular dynamics simulations

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Abstract

The integration of nucleic acids with nanomaterials has attracted great attention from various research communities in search of new nanoscale tools for a range of applications, from electronics to biomedical uses. MXenes are a new class of multielement 2D materials baring exciting properties mostly directed to energy-related fields. These advanced materials are now beginning to enter the biomedical field given their biocompatibility, hydrophilicity and near-infrared absorption. Herein, we elucidate the interaction of MXene Ti3C2Tx with fluorophore-tagged DNA by fluorescence measurements and molecular dynamics simulations. The system showed potential for biosensing with unequivocal detection at picomole levels and single-base discrimination. We found that this material possesses a kinetically unique entrapment/release behavior, with potential implications in time-controlled biomolecule delivery. Our findings present MXenes as platforms for binding nucleic acids, contributing to their potential for hybridization-based biosensing and related bio-applications.

Graphical abstract: Interaction of single- and double-stranded DNA with multilayer MXene by fluorescence spectroscopy and molecular dynamics simulations

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Publication details

The article was received on 20 Jun 2019, accepted on 09 Sep 2019 and first published on 23 Sep 2019


Article type: Edge Article
DOI: 10.1039/C9SC03049B
Chem. Sci., 2019, Advance Article
  • Open access: Creative Commons BY license
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    Interaction of single- and double-stranded DNA with multilayer MXene by fluorescence spectroscopy and molecular dynamics simulations

    C. L. Manzanares-Palenzuela, A. M. Pourrahimi, J. Gonzalez-Julian, Z. Sofer, M. Pykal, M. Otyepka and M. Pumera, Chem. Sci., 2019, Advance Article , DOI: 10.1039/C9SC03049B

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