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Bottom-up self-assembly of heterotrimeric nanoparticles and their secondary Janus generations

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Abstract

A bottom-up self-assembly approach is developed for the synthesis of ABC type heterotrimeric nanoparticles, which can be converted into secondary Janus-type silica derivatives. Compared to spherical ones, Janus silica nanoparticles stimulate stronger phagocytosis and transcytosis through intestinal epithelial microfold cells and exhibit higher cargo transport across an in vitro epithelial monolayer model mimicking the human intestinal epithelium.

Graphical abstract: Bottom-up self-assembly of heterotrimeric nanoparticles and their secondary Janus generations

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Publication details

The article was received on 17 Jun 2019, accepted on 19 Sep 2019 and first published on 19 Sep 2019


Article type: Edge Article
DOI: 10.1039/C9SC02961C
Chem. Sci., 2019, Advance Article
  • Open access: Creative Commons BY-NC license
    All publication charges for this article have been paid for by the Royal Society of Chemistry

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    Bottom-up self-assembly of heterotrimeric nanoparticles and their secondary Janus generations

    J. Fu, Z. Gu, Y. Liu, J. Zhang, H. Song, Y. Yang, Y. Yang, O. Noonan, J. Tang and C. Yu, Chem. Sci., 2019, Advance Article , DOI: 10.1039/C9SC02961C

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