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Issue 33, 2019
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A dual photoredox-nickel strategy for remote functionalization via iminyl radicals: radical ring-opening-arylation, -vinylation and -alkylation cascades

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Abstract

A divergent strategy for the remote arylation, vinylation and alkylation of nitriles is described. These processes proceed through the photoredox generation of a cyclic iminyl radical and its following ring-opening reaction. The distal nitrile radical is then engaged in nickel-based catalytic cycles to form C–C bonds with aryl bromides, alkynes and alkyl bromides.

Graphical abstract: A dual photoredox-nickel strategy for remote functionalization via iminyl radicals: radical ring-opening-arylation, -vinylation and -alkylation cascades

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Submitted
29 May 2019
Accepted
26 Jun 2019
First published
27 Jun 2019

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2019,10, 7728-7733
Article type
Edge Article

A dual photoredox-nickel strategy for remote functionalization via iminyl radicals: radical ring-opening-arylation, -vinylation and -alkylation cascades

E. M. Dauncey, S. U. Dighe, J. J. Douglas and D. Leonori, Chem. Sci., 2019, 10, 7728
DOI: 10.1039/C9SC02616A

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