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Proline-promoted dehydroxylation of α-ketols

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Abstract

A new single-step proline-potassium acetate promoted reductive dehydroxylation of α-ketols is reported. We introduce the unexplored reactivity of proline and, for the first time, reveal its ability to function as a reducing agent. The developed metal-free and open-flask operation generally results in good yields. Our protocol allows the challenging selective dehydroxylation of hydroxyketones without affecting other functional groups.

Graphical abstract: Proline-promoted dehydroxylation of α-ketols

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Publication details

The article was received on 24 May 2019, accepted on 17 Aug 2019 and first published on 19 Aug 2019


Article type: Edge Article
DOI: 10.1039/C9SC02543J
Chem. Sci., 2019, Advance Article
  • Open access: Creative Commons BY license
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    Proline-promoted dehydroxylation of α-ketols

    Y. Mostinski, D. Lankri, Y. Konovalov, R. Nataf and D. Tsvelikhovsky, Chem. Sci., 2019, Advance Article , DOI: 10.1039/C9SC02543J

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