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Issue 40, 2019
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Proline-promoted dehydroxylation of α-ketols

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Abstract

A new single-step proline-potassium acetate promoted reductive dehydroxylation of α-ketols is reported. We introduce the unexplored reactivity of proline and, for the first time, reveal its ability to function as a reducing agent. The developed metal-free and open-flask operation generally results in good yields. Our protocol allows the challenging selective dehydroxylation of hydroxyketones without affecting other functional groups.

Graphical abstract: Proline-promoted dehydroxylation of α-ketols

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Supplementary files

Article information


Submitted
24 May 2019
Accepted
17 Aug 2019
First published
19 Aug 2019

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2019,10, 9345-9350
Article type
Edge Article

Proline-promoted dehydroxylation of α-ketols

Y. Mostinski, D. Lankri, Y. Konovalov, R. Nataf and D. Tsvelikhovsky, Chem. Sci., 2019, 10, 9345
DOI: 10.1039/C9SC02543J

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