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Electrochemical oxidation induced selective tyrosine bioconjugation for the modification of biomolecules

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Abstract

Directly introducing a beneficial functional group into biomolecules under mild, clean and easy-to-handle conditions is of great importance in the field of chemical biology and pharmacology. Herein, we described an electrochemical strategy to perform the bioconjugation of tyrosine residues with phenothiazine derivatives in a rapid and simple manner. In this electrochemical system, various polypeptides and proteins were successfully labelled with excellent site- and chemo-selectivity, and metals, oxidants or additives were also avoided.

Graphical abstract: Electrochemical oxidation induced selective tyrosine bioconjugation for the modification of biomolecules

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The article was received on 07 May 2019, accepted on 07 Jul 2019 and first published on 08 Jul 2019


Article type: Edge Article
DOI: 10.1039/C9SC02218J
Chem. Sci., 2019, Advance Article
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    Electrochemical oxidation induced selective tyrosine bioconjugation for the modification of biomolecules

    C. Song, K. Liu, Z. Wang, B. Ding, S. Wang, Y. Weng, C. Chiang and A. Lei, Chem. Sci., 2019, Advance Article , DOI: 10.1039/C9SC02218J

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