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Selective single C–F bond arylation of trifluoromethylalkene derivatives

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Abstract

A strategically novel single C–F bond functionalization of CF3-derived molecules, which shows a prominent advantage for the expedient construction of difluoromethylene-bridged organic scaffolds, is disclosed. The reported protocol consists of SN2′ amination, N-alkylation and palladium-catalyzed allylic substitution reactions, which enables straightforward arylation and alkenylation of vinyltrifluoromethane derivatives. Furthermore, this strategy is characterized by its broad substrate scope with respect to both CF3-alkene and arylboronic acid derivatives.

Graphical abstract: Selective single C–F bond arylation of trifluoromethylalkene derivatives

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Publication details

The article was received on 20 Apr 2019, accepted on 04 Aug 2019 and first published on 05 Aug 2019


Article type: Edge Article
DOI: 10.1039/C9SC01966A
Chem. Sci., 2019, Advance Article
  • Open access: Creative Commons BY-NC license
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    Selective single C–F bond arylation of trifluoromethylalkene derivatives

    L. Tang, Z. Liu, W. She and C. Feng, Chem. Sci., 2019, Advance Article , DOI: 10.1039/C9SC01966A

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