Jump to main content
Jump to site search

Issue 28, 2019
Previous Article Next Article

Isolated α-turn and incipient γ-helix

Author affiliations

Abstract

The unique abilities of homo-oligo-adamantyl peptides to adopt α- and γ-turn conformations are demonstrated by X-ray diffraction, and NMR and FT-IR absorption spectroscopies. Assembled by an Ugi multiple component reaction strategy, Nα-formyl-adamantyl tripeptide iso-propyl and tert-butyl amides are respectively found to adopt an isolated α-turn and an incipient γ-helix conformation by X-ray diffraction crystallography. The shortest example of a single α-turn with ideal geometry is observed in the crystalline state. In solution both peptides predominantly assume γ-helical structures.

Graphical abstract: Isolated α-turn and incipient γ-helix

Back to tab navigation

Supplementary files

Publication details

The article was received on 05 Apr 2019, accepted on 07 Jun 2019 and first published on 10 Jun 2019


Article type: Edge Article
DOI: 10.1039/C9SC01683J
Chem. Sci., 2019,10, 6908-6914
  • Open access: Creative Commons BY license
    All publication charges for this article have been paid for by the Royal Society of Chemistry

  •   Request permissions

    Isolated α-turn and incipient γ-helix

    F. M. Mir, M. Crisma, C. Toniolo and W. D. Lubell, Chem. Sci., 2019, 10, 6908
    DOI: 10.1039/C9SC01683J

    This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements