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Facile synthesis of supported Ru–Triphos catalysts for continuous flow application in selective nitrile reduction

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Abstract

The selective catalytic hydrogenation of nitriles represents an important but challenging transformation for many homogeneous and heterogeneous catalysts. Herein, we report the efficient and modular solid-phase synthesis of immobilized Triphos-type ligands in very high yields, involving only minimal work-up procedures. The corresponding supported ruthenium–Triphos catalysts are tested in the hydrogenation of various nitriles. Under mild conditions and without the requirement of additives, the tunable supported catalyst library provides selective access to both primary amines and secondary imines. Moreover, the first application of a Triphos-type catalyst in a continuous flow process is presented demonstrating high catalyst life-time over at least 195 hours without significant activity loss.

Graphical abstract: Facile synthesis of supported Ru–Triphos catalysts for continuous flow application in selective nitrile reduction

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Publication details

The article was received on 22 Mar 2019, accepted on 22 Jul 2019 and first published on 23 Jul 2019


Article type: Edge Article
DOI: 10.1039/C9SC01415B
Chem. Sci., 2019, Advance Article
  • Open access: Creative Commons BY-NC license
    All publication charges for this article have been paid for by the Royal Society of Chemistry

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    Facile synthesis of supported Ru–Triphos catalysts for continuous flow application in selective nitrile reduction

    R. Konrath, F. J. L. Heutz, N. Steinfeldt, N. Rockstroh and P. C. J. Kamer, Chem. Sci., 2019, Advance Article , DOI: 10.1039/C9SC01415B

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