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Designing stable, hierarchical peptide fibers from block co-polypeptide sequences

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Abstract

Natural materials, such as collagen, can assemble with multiple levels of organization in solution. Achieving a similar degree of control over morphology, stability and hierarchical organization with equilibrium synthetic materials remains elusive. For the assembly of peptidic materials the process is controlled by a complex interplay between hydrophobic interactions, electrostatics and secondary structure formation. Consequently, fine tuning the thermodynamics and kinetics of assembly remains extremely challenging. Here, we synthesized a set of block co polypeptides with varying hydrophobicity and ability to form secondary structure. From this set we select a sequence with balanced interactions that results in the formation of high-aspect ratio thermodynamically favored nanotubes, stable between pH 2 and 12 and up to 80 °C. This stability permits their hierarchical assembly into bundled nanotube fibers by directing the pH and inducing complementary zwitterionic charge behavior. This block co-polypeptide design strategy, using defined sequences, provides a straightforward approach to creating complex hierarchical peptide-based assemblies with tunable interactions.

Graphical abstract: Designing stable, hierarchical peptide fibers from block co-polypeptide sequences

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Publication details

The article was received on 15 Feb 2019, accepted on 02 Aug 2019 and first published on 07 Aug 2019


Article type: Edge Article
DOI: 10.1039/C9SC00800D
Chem. Sci., 2019, Advance Article
  • Open access: Creative Commons BY license
    All publication charges for this article have been paid for by the Royal Society of Chemistry

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    Designing stable, hierarchical peptide fibers from block co-polypeptide sequences

    M. M. J. van Rijt, A. Ciaffoni, A. Ianiro, M. Moradi, A. L. Boyle, A. Kros, H. Friedrich, N. A. J. M. Sommerdijk and J. P. Patterson, Chem. Sci., 2019, Advance Article , DOI: 10.1039/C9SC00800D

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