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Issue 21, 2019
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Development of 68Ga-labelled ultrasound microbubbles for whole-body PET imaging

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Abstract

Microbubble (MB) contrast agents have revolutionalised the way ultrasound (US) imaging can be used clinically and pre-clinically. Contrast-enhanced US offers improvements in soft-tissue contrast, as well as the ability to visualise disease processes at the molecular level. However, its inability to provide in vivo whole-body imaging can hamper the development of new MB formulations. Herein, we describe a fast and efficient method for achieving 68Ga-labelling of MBs after a direct comparison of two different strategies. The optimised approach produces 68Ga-labelled MBs in good yields through the bioorthogonal inverse-electron-demand Diel–Alder reaction between a trans-cyclooctene-modified phospholipid and a new tetrazine-bearing HBED-CC chelator. The ability to noninvasively study the whole-body distribution of 68Ga-labelled MBs was demonstrated in vivo using positron emission tomography (PET). This method could be broadly applicable to other phospholipid-based formulations, providing accessible solutions for in vivo tracking of MBs.

Graphical abstract: Development of 68Ga-labelled ultrasound microbubbles for whole-body PET imaging

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Supplementary files

Article information


Submitted
08 Feb 2019
Accepted
18 Apr 2019
First published
01 May 2019

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2019,10, 5603-5615
Article type
Edge Article

Development of 68Ga-labelled ultrasound microbubbles for whole-body PET imaging

J. Hernández-Gil, M. Braga, B. I. Harriss, L. S. Carroll, C. H. Leow, M. Tang, E. O. Aboagye and N. J. Long, Chem. Sci., 2019, 10, 5603 DOI: 10.1039/C9SC00684B

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