Issue 11, 2019

Reductive annulations of arylidene malonates with unsaturated electrophiles using photoredox/Lewis acid cooperative catalysis

Abstract

A cooperative Lewis acid/photocatalytic reduction of salicylaldehyde-derived arylidene malonates provides access to a versatile, stabilized radical anion enolate. Using these unusual umpolung operators, we have developed a novel route to access densely functionalized carbo- and heterocycles through a radical annulation addition pathway.

Graphical abstract: Reductive annulations of arylidene malonates with unsaturated electrophiles using photoredox/Lewis acid cooperative catalysis

Associated articles

Supplementary files

Article information

Article type
Edge Article
Submitted
18 Jan 2019
Accepted
03 Feb 2019
First published
06 Feb 2019
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2019,10, 3353-3359

Reductive annulations of arylidene malonates with unsaturated electrophiles using photoredox/Lewis acid cooperative catalysis

R. C. Betori, B. R. McDonald and K. A. Scheidt, Chem. Sci., 2019, 10, 3353 DOI: 10.1039/C9SC00302A

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