Jump to main content
Jump to site search

Issue 3, 2019
Previous Article Next Article

Comment on Enantioselective total synthesis of (−)-colchicine, (+)-demecolcinone and metacolchicine: determination of the absolute configurations of the latter two alkaloids by B. Chen, X. Liu, Y.-J. Hu, D.-M. Zhang, L. Deng, J. Lu, L. Min, W.-C. Ye and C.-C. Li, Chem. Sci., 2017, 8, 4961–4966

Author affiliations

Abstract

We note that some features of the NMR spectra deposited for the purported isomeric metacolchicines (Chem. Sci.8, 4961 (2017)) are not compatible with the assignment of those isomers as being atrop-diastereomers. We suggest that there are no such isomeric metacolchicines as reported. The differences in the spectra could rather be a consequence of a (precedented) monomer/dimer equilibrium of metacolchicine in solution.

Graphical abstract: Comment on Enantioselective total synthesis of (−)-colchicine, (+)-demecolcinone and metacolchicine: determination of the absolute configurations of the latter two alkaloids by B. Chen, X. Liu, Y.-J. Hu, D.-M. Zhang, L. Deng, J. Lu, L. Min, W.-C. Ye and C.-C. Li, Chem. Sci., 2017, 8, 4961–4966

Back to tab navigation

Publication details

The article was received on 15 Aug 2017, accepted on 28 Nov 2018 and first published on 18 Dec 2018


Article type: Comment
DOI: 10.1039/C8SC90247J
Citation: Chem. Sci., 2019,10, 943-945
  • Open access: Creative Commons BY license
  •   Request permissions

    Comment on Enantioselective total synthesis of (−)-colchicine, (+)-demecolcinone and metacolchicine: determination of the absolute configurations of the latter two alkaloids by B. Chen, X. Liu, Y.-J. Hu, D.-M. Zhang, L. Deng, J. Lu, L. Min, W.-C. Ye and C.-C. Li, Chem. Sci., 2017, 8, 4961–4966

    R. W. Hoffmann, H. Schmalz, U. Koert and G. K. Pierens, Chem. Sci., 2019, 10, 943
    DOI: 10.1039/C8SC90247J

    This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements