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Hydroxy group-enabled highly regio- and stereo-selective hydrocarboxylation of alkynes

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Abstract

Here we present an example of utilizing hydroxy groups for regioselectivity control in the addition reaction of alkynes—a highly efficient Pd-catalyzed syn-hydrocarboxylation of readily available 2-alkynylic alcohols with CO in the presence of alcohols with an unprecedented regioselectivity affording 3-hydroxy-2(E)-alkenoates. The role of the hydroxy group has been carefully studied. The synthetic potential of the products has also been demonstrated.

Graphical abstract: Hydroxy group-enabled highly regio- and stereo-selective hydrocarboxylation of alkynes

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Publication details

The article was received on 22 Dec 2018, accepted on 16 Apr 2019 and first published on 17 Apr 2019


Article type: Edge Article
DOI: 10.1039/C8SC05743E
Chem. Sci., 2019, Advance Article
  • Open access: Creative Commons BY license
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    Hydroxy group-enabled highly regio- and stereo-selective hydrocarboxylation of alkynes

    C. Huang, H. Qian, W. Zhang and S. Ma, Chem. Sci., 2019, Advance Article , DOI: 10.1039/C8SC05743E

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