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Issue 14, 2019
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Toward ideal carbon dioxide functionalization

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Abstract

This Perspective recapitulates recent developments of carbon dioxide utilization in carbon–carbon bond formation reactions, with an intention of paving a way toward sustainable CO2-functionalization and its tangible applications in synthetic chemistry. CO2 functionalization reactions possess intrinsic drawbacks: the high kinetic inertness and thermodynamic stability of CO2. Numerous procedures for CO2 utilization depend on energy-intensive processes (i.e. high pressure and/or temperature), often solely relying on reactive substrates, hampering its general applications. Recent efforts thus have been dedicated to catalytic CO2-utilization under ambient reaction conditions, however, it is still limited to a few activation modes and the use of reactive substrates. Herein, ideal CO2-functionalization with particular emphasis on sustainability will be discussed based on the following sub-categories; (1) metal-catalyzed ‘reductive’ carboxylation reaction of halides, olefins and allyl alcohols, (2) photochemical CO2-utilization, (3) redox-neutral CO2-functionalization, and (4) enantioselective catalysis incorporating CO2 to form C–CO2 bonds (excluding strain mediated reactions with epoxide- and aziridine-based substrates). Recent progress in these fields will be discussed with the proposed reaction mechanisms and selected examples, highlighting redox-neutral, umpolung, and asymmetric carboxylation to postulate ideal CO2 functionalization reactions to be developed in the near future.

Graphical abstract: Toward ideal carbon dioxide functionalization

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Publication details

The article was received on 11 Dec 2018, accepted on 20 Feb 2019 and first published on 20 Feb 2019


Article type: Perspective
DOI: 10.1039/C8SC05539D
Chem. Sci., 2019,10, 3905-3926
  • Open access: Creative Commons BY license
    All publication charges for this article have been paid for by the Royal Society of Chemistry

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    Toward ideal carbon dioxide functionalization

    Y. Yang and J. Lee, Chem. Sci., 2019, 10, 3905
    DOI: 10.1039/C8SC05539D

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