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Activatable near-infrared emission-guided on-demand administration of photodynamic anticancer therapy with a theranostic nanoprobe

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Abstract

Development of theranostic probes that can be used to identify tumors and direct the on-demand drug administration to cancers is ongoing but remains challenging. Herein, we report a theranostic platform composed of a H2S-activated imaging probe and a light-sensitive drug. The designed probe affords advantages of H2S-activated NIR emission light-up and efficient 1O2 generation, enabling the selective visualization of H2S-rich cancers and the subsequent imaging-directed on-demand light exposure to the detected cancers while leaving normal tissues untouched. Such controllable administration of photodynamic anticancer therapy maximizes the therapeutic efficiency and minimizes side effects. This work should facilitate significant advances toward precise diagnosis and treatment of cancer.

Graphical abstract: Activatable near-infrared emission-guided on-demand administration of photodynamic anticancer therapy with a theranostic nanoprobe

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Publication details

The article was received on 31 Oct 2018, accepted on 03 Jan 2019 and first published on 09 Jan 2019


Article type: Edge Article
DOI: 10.1039/C8SC04854A
Citation: Chem. Sci., 2019, Advance Article
  • Open access: Creative Commons BY-NC license
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    Activatable near-infrared emission-guided on-demand administration of photodynamic anticancer therapy with a theranostic nanoprobe

    R. Wang, K. Dong, G. Xu, B. Shi, T. Zhu, P. Shi, Z. Guo, W. Zhu and C. Zhao, Chem. Sci., 2019, Advance Article , DOI: 10.1039/C8SC04854A

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