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Deciphering the intersystem crossing in near-infrared BODIPY photosensitizers for highly efficient photodynamic therapy

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Abstract

Deciphering singlet-to-triplet intersystem crossing (ISC) in organic near-infrared photosensitizers (PSs) is of fundamental importance in the designing of high-performance PSs to boost the clinical usage of photodynamic therapy (PDT). However, in-depth investigations of the ISC dynamics in near-infrared PSs have not been performed to date. Here, systematical investigations of the ISC dynamics in organic near-infrared BODIPY derivatives are presented, in which a multi-channel yet remarkably efficient ISC process is revealed by ultrafast femtosecond transient absorption (fs-TA) spectroscopy and theoretical calculation. The fs-TA verifies an exceptionally enhanced ISC efficiency (ΦISC = 91%) in iodine-substituted BODIPY (2I-BDP) which is further supported by the calculation results. This endows 2I-BDP with an ultrahigh singlet oxygen quantum yield (ΦΔ = 88%), thus enabling a proof-of-concept application of highly efficient PDT in vivo under ultralow near-infrared light power density (10 mW cm−2). The in-depth understanding of ISC dynamics in organic near-infrared materials may provide valuable guidance in the designing of novel organic theranostic materials for clinical cancer treatment.

Graphical abstract: Deciphering the intersystem crossing in near-infrared BODIPY photosensitizers for highly efficient photodynamic therapy

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Publication details

The article was received on 30 Oct 2018, accepted on 17 Jan 2019 and first published on 22 Jan 2019


Article type: Edge Article
DOI: 10.1039/C8SC04840A
Citation: Chem. Sci., 2019, Advance Article
  • Open access: Creative Commons BY license
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    Deciphering the intersystem crossing in near-infrared BODIPY photosensitizers for highly efficient photodynamic therapy

    X. Miao, W. Hu, T. He, H. Tao, Q. Wang, R. Chen, L. Jin, H. Zhao, X. Lu, Q. Fan and W. Huang, Chem. Sci., 2019, Advance Article , DOI: 10.1039/C8SC04840A

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