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Rationally designed pure-inorganic upconversion nanoprobes for ultra-highly selective hydrogen sulfide imaging and elimination in vivo

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Abstract

Lung injury is a hydrogen sulfide (H2S)-associated complication with high mortality in acute pancreatitis (AP) cases. Herein, we used Prussian Blue (PB) as a H2S-responsive acceptor to develop a novel pure-inorganic upconversion nanoprobe for detecting and eliminating H2S, which can be used for diagnosing AP and alleviating lung injury. Upconversion nanoprobes with 5 nm PB shells were optimized to achieve outstanding in vitro H2S detection capacity (linear range: 0–150 μM, LOD: 50 nM), which met the in vivo serum H2S range, and thus were feasible for imaging H2S in vivo. More importantly, when combined with the traditional H2S synthetase inhibitor DL-PAG, the nanoprobes also served as a therapeutic agent that synergistically alleviated lung injury. As PB is an FDA-approved drug, our work proposes a potential clinical modality for the early diagnosis of AP, which will decrease lung injury-induced mortality and increase the survival rates of AP cases.

Graphical abstract: Rationally designed pure-inorganic upconversion nanoprobes for ultra-highly selective hydrogen sulfide imaging and elimination in vivo

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Publication details

The article was received on 08 Oct 2018, accepted on 12 Nov 2018 and first published on 12 Nov 2018


Article type: Edge Article
DOI: 10.1039/C8SC04464C
Citation: Chem. Sci., 2019, Advance Article
  • Open access: Creative Commons BY-NC license
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    Rationally designed pure-inorganic upconversion nanoprobes for ultra-highly selective hydrogen sulfide imaging and elimination in vivo

    Y. Liu, Q. Jia, X. Zhai, F. Mao, A. Jiang and J. Zhou, Chem. Sci., 2019, Advance Article , DOI: 10.1039/C8SC04464C

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