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Continuous-flow crystallisation in 3D-printed compact devices

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Abstract

A flexible and cost-effective methodology to develop compact flow devices with heat exchange ability is presented here. Additive manufacturing techniques allow the rapid design and manufacture of modular jacketed flow devices, where heat exchange can be modelled and controlled to generate efficient devices for applications in continuous-flow cooling crystallisation. As a proof of concept, the crystallisation of paracetamol has been demonstrated. The manufactured devices are effective in crystallising form II paracetamol employing metacetamol as a co-crystallising agent.

Graphical abstract: Continuous-flow crystallisation in 3D-printed compact devices

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Publication details

The article was received on 11 May 2019, accepted on 23 Jul 2019 and first published on 23 Jul 2019


Article type: Paper
DOI: 10.1039/C9RE00188C
React. Chem. Eng., 2019, Advance Article

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    Continuous-flow crystallisation in 3D-printed compact devices

    O. Okafor, K. Robertson, R. Goodridge and V. Sans, React. Chem. Eng., 2019, Advance Article , DOI: 10.1039/C9RE00188C

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