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Rapid route design of AZD7594

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A wide variety of technology platforms were used to rapidly select a commercial manufacturing route to the inhaled glucocorticoid receptor modulator AZD7594. This collaborative approach to the route design employed idea generation, high-throughput salt formation, solubility and chemical reaction screening, process analytical techniques and factorial experimental design to propose, assess and select the new strategic route within a five-month window. The selected route is currently undergoing further process development and optimisation and will be implemented in future manufacturing campaigns to supply drug substance for ongoing clinical studies and ultimately for the commercially marketed product.

Graphical abstract: Rapid route design of AZD7594

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The article was received on 15 Mar 2019, accepted on 03 Jun 2019 and first published on 05 Jun 2019

Article type: Paper
DOI: 10.1039/C9RE00118B
React. Chem. Eng., 2019, Advance Article

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    Rapid route design of AZD7594

    H. L. Carter, A. W. Connor, R. Hart, J. McCabe, A. C. McIntyre, A. E. McMillan, N. R. Monks, A. K. Mullen, T. O. Ronson, A. Steven, S. Tomasi and S. D. Yates, React. Chem. Eng., 2019, Advance Article , DOI: 10.1039/C9RE00118B

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