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Laboratory of the future: a modular flow platform with multiple integrated PAT tools for multistep reactions

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Abstract

Currently, the monitoring of multistep continuous flow processes by multiple analytical sources is still seen as a resource intensive and specialized activity. In this article, the coupling of a modular microreactor platform with real-time monitoring by inline IR and NMR, in addition to online UPLC, is described. Using this platform, we rapidly generated experimental data (17 iterations in under 2 hours) to access information on the different chemical species at multiple points within the reactor and to generate process understanding. We highlight the application of the platform in the optimization of a multistep organolithium transformation. The optimized continuous flow conditions were demonstrated in a scale-out experiment with in-process monitoring to afford the desired product in 70% isolated yield and provided a throughput of 4.2 g h−1.

Graphical abstract: Laboratory of the future: a modular flow platform with multiple integrated PAT tools for multistep reactions

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Publication details

The article was received on 24 Feb 2019, accepted on 08 Apr 2019 and first published on 08 Apr 2019


Article type: Paper
DOI: 10.1039/C9RE00087A
Citation: React. Chem. Eng., 2019, Advance Article
  • Open access: Creative Commons BY-NC license
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    Laboratory of the future: a modular flow platform with multiple integrated PAT tools for multistep reactions

    P. Sagmeister, J. D. Williams, C. A. Hone and C. O. Kappe, React. Chem. Eng., 2019, Advance Article , DOI: 10.1039/C9RE00087A

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