Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 22nd May 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.



Development of an automated kinetic profiling system with online HPLC for reaction optimization

Author affiliations

Abstract

Automated kinetic profiling is a valuable tool for providing insights into key mechanistic features of complex catalytic systems. In an attempt to optimize a palladium-catalyzed Suzuki cross-coupling reaction, automated kinetic profiling was utilized with offline liquid chromatography to monitor reaction progress. Upon uncovering analytical sample instability issues, an online HPLC capability was developed and implemented through integration of a Chemspeed liquid handling robot with an Agilent HPLC to facilitate automated reaction set-up and monitoring. Application of this capability resulted in the observation that precatalyst activation was a key factor influencing the reaction rate. Leveraging this mechanistic insight, a more efficient method to access the active catalyst was developed. This change resulted in a five-fold increase in the reaction rate.

Graphical abstract: Development of an automated kinetic profiling system with online HPLC for reaction optimization

Back to tab navigation

Supplementary files

Publication details

The article was received on 23 Feb 2019, accepted on 25 Mar 2019 and first published on 29 Mar 2019


Article type: Communication
DOI: 10.1039/C9RE00086K
React. Chem. Eng., 2019, Advance Article

  •   Request permissions

    Development of an automated kinetic profiling system with online HPLC for reaction optimization

    M. Christensen, F. Adedeji, S. Grosser, K. Zawatzky, Y. Ji, J. Liu, J. A. Jurica, J. R. Naber and J. E. Hein, React. Chem. Eng., 2019, Advance Article , DOI: 10.1039/C9RE00086K

Search articles by author

Spotlight

Advertisements