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Green and catalyst-free synthesis of deoxyarbutin in continuous-flow

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Abstract

A one-step catalyst-free continuous-flow etherification protocol has been developed for the preparation of deoxyarbutin. The starting material hydroquinone was etherified with 3,4-dihydro-2H-pyran (DHP) to gain deoxyarbutin directly. A material recycling method was established to address the drawback of low per pass conversion which is caused by the reversible equilibrium of this reaction. The continuous-flow methodology is effective in inhibiting the double etherification side reaction to realize the facile and highly efficient preparation of deoxyarbutin.

Graphical abstract: Green and catalyst-free synthesis of deoxyarbutin in continuous-flow

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Publication details

The article was received on 22 Feb 2019, accepted on 27 Feb 2019 and first published on 28 Feb 2019


Article type: Paper
DOI: 10.1039/C9RE00084D
Citation: React. Chem. Eng., 2019, Advance Article

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    Green and catalyst-free synthesis of deoxyarbutin in continuous-flow

    X. Xie, S. Xie, H. Yao, X. Ye, Z. Yu and W. Su, React. Chem. Eng., 2019, Advance Article , DOI: 10.1039/C9RE00084D

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