Jump to main content
Jump to site search


Exploring the generation and use of acylketenes with continuous flow processes

Author affiliations

Abstract

The generation and use of reactive intermediates is well suited to continuous flow processing owing to the ability to scale up reactions, contain hazards and heat solvents past their atmospheric temperature boiling points. Herein we explore the chemistry of acylketenes, generated from commercially available 2,2,6-trimethyl-4H-1,3-dioxin-4-one (TMD, 10) under continuous flow conditions. The developed flow chemistry system is capable of permitting a wide range of applications of these acylketene intermediates, including access to equilibrating processes that result in ketone exchange. Some of the dioxinone products resulting from this study are destabilised towards acylketene generation, this is demonstrated through their ability to generate acylketene at lower reaction temperatures.

Graphical abstract: Exploring the generation and use of acylketenes with continuous flow processes

Back to tab navigation

Supplementary files

Publication details

The article was received on 15 Feb 2019, accepted on 12 Mar 2019 and first published on 25 Mar 2019


Article type: Communication
DOI: 10.1039/C9RE00072K
Citation: React. Chem. Eng., 2019, Advance Article

  •   Request permissions

    Exploring the generation and use of acylketenes with continuous flow processes

    R. Galaverna, T. McBride, J. C. Pastre and D. L. Browne, React. Chem. Eng., 2019, Advance Article , DOI: 10.1039/C9RE00072K

Search articles by author

Spotlight

Advertisements