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From enabling technologies to medicinal mechanochemistry: an eco-friendly access to hydantoin-based active pharmaceutical ingredients

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Abstract

The preparation of hydantoin scaffolds using modern non-conventional activation methods is herein described. Special attention is devoted to the preparation of hydantoin-based Active Pharmaceutical Ingredients (APIs) by mechanochemistry, highlighting its advantages compared to classical solution procedures, opening new perspectives in the sustainable preparation of useful scaffolds for the pharmaceutical industry.

Graphical abstract: From enabling technologies to medicinal mechanochemistry: an eco-friendly access to hydantoin-based active pharmaceutical ingredients

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Publication details

The article was received on 13 Feb 2019, accepted on 28 Mar 2019 and first published on 28 Mar 2019


Article type: Minireview
DOI: 10.1039/C9RE00069K
Citation: React. Chem. Eng., 2019, Advance Article

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    From enabling technologies to medicinal mechanochemistry: an eco-friendly access to hydantoin-based active pharmaceutical ingredients

    E. Colacino, A. Porcheddu, C. Charnay and F. Delogu, React. Chem. Eng., 2019, Advance Article , DOI: 10.1039/C9RE00069K

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