Issue 3, 2019

The coupling of in-flow reaction with continuous flow seedless tubular crystallization

Abstract

The direct coupling between a continuous flow-assisted acetylation reaction of salicylic acid and the subsequent crystallisation of aspirin in a continuous flow tubular reactor or nucleator is investigated. The design of the reactor relies on a 3 minute residence time, followed by quenching with water prior to cooling inside the tubular nucleator. By appropriate selection of the temperature of the nucleation step, the number of nuclei formed in the tubular setup is accurately controlled. In this way, pure crystalline aspirin is continuously obtained with a desired mean crystal size between 3 μm and 300 μm and a reduced dispersion grade, avoiding seeding and micronisation steps.

Graphical abstract: The coupling of in-flow reaction with continuous flow seedless tubular crystallization

Article information

Article type
Paper
Submitted
23 Nov 2018
Accepted
18 Jan 2019
First published
18 Jan 2019

React. Chem. Eng., 2019,4, 516-522

The coupling of in-flow reaction with continuous flow seedless tubular crystallization

B. Rimez, J. Septavaux and B. Scheid, React. Chem. Eng., 2019, 4, 516 DOI: 10.1039/C8RE00313K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements