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Issue 2, 2019
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Role of hexafluoroisopropanol in C–H activation

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1,1,1,3,3,3-Hexafluoroisopropanol (HFIP) has emerged as an attractive tool in developing and facilitating C–H activation/functionalizations. The hydrogen bond donating ability of this solvent coupled with its enhanced acidity and reduced nucleophilicity has played an integral part in boosting the reactivity and stereoselectivity of C–H functionalization reactions. Several C–H activation reactions necessitate the requirement of HFIP which plays a central role in developing these methodologies. Herein, this report showcases the importance of HFIP in developing C–H activation reactions in organic synthesis.

Graphical abstract: Role of hexafluoroisopropanol in C–H activation

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Publication details

The article was received on 30 Sep 2018, accepted on 30 Oct 2018 and first published on 30 Oct 2018

Article type: Minireview
DOI: 10.1039/C8RE00225H
Citation: React. Chem. Eng., 2019,4, 244-253

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    Role of hexafluoroisopropanol in C–H activation

    S. K. Sinha, T. Bhattacharya and D. Maiti, React. Chem. Eng., 2019, 4, 244
    DOI: 10.1039/C8RE00225H

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