Jump to main content
Jump to site search

Issue 69, 2019
Previous Article Next Article

Synthesis of MeBmt and related derivatives via syn-selective ATH-DKR

Author affiliations

Abstract

The unusual α-amino, β-hydroxy acid MeBmt is a key structural feature of cyclosporin A, an important naturally occurring immunosuppressant and antiviral agent. We present a convergent synthesis of MeBmt which relies on new aspects of dynamic kinetic resolution (DKR) to establish simultaneously the chirality at C(2) and C(3). We also show that this route is applicable to the synthesis of other derivatives.

Graphical abstract: Synthesis of MeBmt and related derivatives via syn-selective ATH-DKR

Back to tab navigation

Supplementary files

Article information


Submitted
10 Oct 2019
Accepted
27 Nov 2019
First published
05 Dec 2019

This article is Open Access

RSC Adv., 2019,9, 40336-40339
Article type
Paper

Synthesis of MeBmt and related derivatives via syn-selective ATH-DKR

A. Rolt, P. M. O'Neill, T. J. Liang and A. V. Stachulski, RSC Adv., 2019, 9, 40336
DOI: 10.1039/C9RA08256E

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

Reproduced material should be attributed as follows:

  • For reproduction of material from NJC:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
  • For reproduction of material from PCCP:
    [Original citation] - Published by the PCCP Owner Societies.
  • For reproduction of material from PPS:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
  • For reproduction of material from all other RSC journals:
    [Original citation] - Published by The Royal Society of Chemistry.

Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.


Social activity

Search articles by author

Spotlight

Advertisements