Issue 51, 2019
From the journal:

RSC Advances

Formal synthesis of (+)-lactacystin from l-serine†

Philip C. Bulman Page, ORCID logo *a   Ross L. Goodyear,a   Yohan Chan,a   Alexandra M. Z. Slawin ORCID logo b  and  Steven M. Allin ORCID logo c  

* Corresponding authors

a School of Chemistry, University of East Anglia, Norwich Research Park, Norwich, Norfolk NR4 7TJ, UK
E-mail: p.page@uea.ac.uk

b School of Chemistry, University of St Andrews, St Andrews, Scotland KY16 9ST, UK

c School of Science & Technology, Nottingham Trent University, Clifton, Nottingham NG11 8NS, UK

Abstract

A formal, stereocontrolled synthesis of lactacystin has been completed from t-Bu-O-L-serine, providing the key intermediate 13, also useful for the generation of a range of C-9 analogues.

Graphical abstract: Formal synthesis of (+)-lactacystin from l-serine

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Article information

DOI
https://doi.org/10.1039/C9RA07244F
Article type
Paper
Submitted
29 Jul 2019
Accepted
12 Sep 2019
First published
24 Sep 2019
This article is Open Access
Creative Commons BY license

RSC Adv., 2019,9, 30019-30032

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Formal synthesis of (+)-lactacystin from L-serine

P. C. Bulman Page, R. L. Goodyear, Y. Chan, A. M. Z. Slawin and S. M. Allin, RSC Adv., 2019, 9, 30019 DOI: 10.1039/C9RA07244F

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