Issue 65, 2019
From the journal:

RSC Advances

A supramolecular hydrophobic guest transport system based on a biological macrocycle†

Yan Ge,a   Xin Shen,a   Hongqian Cao,a   Yuchong Hao,a   Lin Jin,a   Jie Shang,a   Yangxin Wang,a   Tiezheng Pan*a  and  Zhenhui Qi*ab  

* Corresponding authors

a Sino-German Joint Research Lab for Space Biomaterials and Translational Technology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi, China
E-mail: pantiezheng@nwpu.edu.cn, qi@nwpu.edu.cn

b Institute of Biomedical Materials & Engineering (IBME), Northwestern Polytechincial University, Xi'an, Shaanxi, P. R. China

Abstract

A protein-based macrocyclic bioactive guest loading system has been developed, which not only provides a stable 10 nm scale lipophilic environment, but also increases the solubility of potent anticancer agent SN38 in its active lactone form in aqueous medium.

Graphical abstract: A supramolecular hydrophobic guest transport system based on a biological macrocycle

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Article information

DOI
https://doi.org/10.1039/C9RA07054K
Article type
Paper
Submitted
15 Aug 2019
Accepted
13 Nov 2019
First published
22 Nov 2019
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2019,9, 38195-38199

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A supramolecular hydrophobic guest transport system based on a biological macrocycle

Y. Ge, X. Shen, H. Cao, Y. Hao, L. Jin, J. Shang, Y. Wang, T. Pan and Z. Qi, RSC Adv., 2019, 9, 38195 DOI: 10.1039/C9RA07054K

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