KOtBu-promoted oxidative dimerizations of 2-methylquinolines to 2-alkenyl bisquinolines with molecular oxygen

Zhen Wang; Jinjin Zhang; Jianxue Shi; Huiqiao Wang

doi:10.1039/C9RA06465F

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KO^tBu-promoted oxidative dimerizations of 2-methylquinolines to 2-alkenyl bisquinolines with molecular oxygen†

Zhen Wang,‡^b Jinjin Zhang,‡^a Jianxue Shi^a and Huiqiao Wang

*^a

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* Corresponding authors

^a College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang, Henan, China
E-mail: huiqiaowang@163.com

^b Department of Pharmacy, Nanyang Medical College, Nanyang, China

Abstract

KO^tBu-promoted oxidative dimerizations of 2-methylquinolines with molecular oxygen as the oxidant have been developed for the first time. The mild reaction conditions allow the homo- and cross-dimerizations of 2-methylquinolines to give functionalized 2-alkenyl bisquinolines in highly trans-selective manners.

This article is part of the themed collection: Editors' Collection: Greener synthetic approaches towards quinoline derivatives

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Article information

DOI: https://doi.org/10.1039/C9RA06465F
Article type: Paper
Submitted: 18 Aug 2019
Accepted: 18 Sep 2019
First published: 23 Sep 2019
This article is Open Access

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RSC Adv., 2019,9, 30139-30143

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KO^tBu-promoted oxidative dimerizations of 2-methylquinolines to 2-alkenyl bisquinolines with molecular oxygen

Z. Wang, J. Zhang, J. Shi and H. Wang, RSC Adv., 2019, 9, 30139 DOI: 10.1039/C9RA06465F

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