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Issue 54, 2019
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Combinatorial synthesis and biological evaluations of (E)-β-trifluoromethyl vinylsulfones as antitumor agents

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Abstract

Combinatorial synthesis of (E)-β-trifluoromethyl vinylsulfones is accomplished through a reaction of alkynes, Togni reagent, and sodium benzenesulfinates in DMSO under metal-free conditions at room temperature. These compounds are evaluated in several assays against different tumor cells. Some hits are identified against ES-2, HO-8910, and K562.

Graphical abstract: Combinatorial synthesis and biological evaluations of (E)-β-trifluoromethyl vinylsulfones as antitumor agents

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Article information


Submitted
15 Aug 2019
Accepted
26 Sep 2019
First published
03 Oct 2019

This article is Open Access

RSC Adv., 2019,9, 31474-31482
Article type
Paper

Combinatorial synthesis and biological evaluations of (E)-β-trifluoromethyl vinylsulfones as antitumor agents

H. Tang, Y. Kuang, J. Zeng, X. Li, W. Zhou and Y. Lu, RSC Adv., 2019, 9, 31474
DOI: 10.1039/C9RA06368D

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