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Issue 62, 2019
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Near-infrared-induced IR780-loaded PLGA nanoparticles for photothermal therapy to treat breast cancer metastasis in bones

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Abstract

Nanodrug-based cancer therapy, especially when treating bone metastases, faces the problem of limited therapeutic efficacy. In this work, we reported a photothermally triggered nanomaterial based on IR780-entrapped poly-lactide-co-glycolide (PLGA) nanoparticles (IR780@PLGA NPs) for the photothermal therapy of bone metastases of breast cancer, in which IR780 converted light into heat to play a role in “burning” the tumors. Anti-tumor therapy studies showed the impressive effectiveness of IR780@PLGA NPs in the photothermal therapy (PTT) of bone metastases. As a result, the IR780@PLGA NPs show a great potential for controlling the bone metastases of breast cancer.

Graphical abstract: Near-infrared-induced IR780-loaded PLGA nanoparticles for photothermal therapy to treat breast cancer metastasis in bones

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Article information


Submitted
26 Jul 2019
Accepted
21 Oct 2019
First published
05 Nov 2019

This article is Open Access

RSC Adv., 2019,9, 35976-35983
Article type
Paper

Near-infrared-induced IR780-loaded PLGA nanoparticles for photothermal therapy to treat breast cancer metastasis in bones

J. Li, H. Hu, Z. Jiang, S. Chen, Y. Pan, Q. Guo, Q. Xing, Z. Jing, Y. Hu and L. Wang, RSC Adv., 2019, 9, 35976
DOI: 10.1039/C9RA05813C

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    [Original citation] - Published by The Royal Society of Chemistry.

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