Issue 54, 2019

Enantioselective bromination of axially chiral cyanoarenes in the presence of bifunctional organocatalysts

Abstract

Enantioselective bromination of axially chiral cyanoarenes bearing high intrinsic rotational barriers via dynamic kinetic resolution using bifunctional organocatalysts is reported. Sequential addition of a brominating reagent in several portions at an optimized temperature was effective in accomplishing high enantioselectivities.

Graphical abstract: Enantioselective bromination of axially chiral cyanoarenes in the presence of bifunctional organocatalysts

Supplementary files

Article information

Article type
Paper
Submitted
18 Jul 2019
Accepted
30 Sep 2019
First published
04 Oct 2019
This article is Open Access
Creative Commons BY license

RSC Adv., 2019,9, 31654-31658

Enantioselective bromination of axially chiral cyanoarenes in the presence of bifunctional organocatalysts

Y. Wada, A. Matsumoto, K. Asano and S. Matsubara, RSC Adv., 2019, 9, 31654 DOI: 10.1039/C9RA05532K

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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