Issue 48, 2019
From the journal:

RSC Advances

Peptidoglycan pathways: there are still more!

Ahmed M. Helal,a   Ahmed M. Sayed,a   Mariam Omara,a   Mohamed M. Elsebaei ORCID logo a  and  Abdelrahman S. Mayhoub ORCID logo *ab  

* Corresponding authors

a Department of Pharmaceutical Organic Chemistry, College of Pharmacy, Al-Azhar University, Cairo 11884, Egypt
E-mail: amayhoub@azhar.edu.eg

b University of Science and Technology, Zewail City of Science and Technology, Giza, Egypt

Abstract

The discovery of 3rd and 4th generations of currently existing classes of antibiotics has not hindered bacterial resistance, which is escalating at an alarming global level. This review follows WHO recommendations through implementing new criteria for newly discovered antibiotics. These recommendations focus on abandoning old scaffolds and hitting new targets. In light of these recommendations, this review discusses seven bacterial proteins that no commercial antibiotics have targeted yet, alongside their reported chemical scaffolds.

Graphical abstract: Peptidoglycan pathways: there are still more!

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Article information

DOI
https://doi.org/10.1039/C9RA04518J
Article type
Review Article
Submitted
16 Jun 2019
Accepted
22 Aug 2019
First published
09 Sep 2019
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2019,9, 28171-28185

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Peptidoglycan pathways: there are still more!

A. M. Helal, A. M. Sayed, M. Omara, M. M. Elsebaei and A. S. Mayhoub, RSC Adv., 2019, 9, 28171 DOI: 10.1039/C9RA04518J

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