Recent advances in direct trifluoromethylation of olefinic C–H bonds
The aim of this review is to provide a comprehensive overview of the direct trifluoromethylation of olefinic C–H bonds with special attention on the mechanistic aspects of the reactions. The review is divided into two major sections. The first focuses exclusively on trifluoromethylation of terminal alkenes, while the second will cover trifluoromethylation of internal alkenes. Literature has been surveyed until the end of April 2019.
- This article is part of the themed collection: Editors' Collection: Fluorine chemistry in medicinal chemistry and chemical biology