Issue 34, 2019, Issue in Progress

Micronutrients encapsulation in enhanced nanoliposomal carriers by a novel preparative technology

Abstract

Micronutrients administration by fortification of staple and complementary foods is a followed strategy to fight malnutrition and micronutrient deficiencies and related pathologies. There is a great industrial interest in preparation of formulations for joint administration of vitamin D3 and vitamin K2 for providing bone support, promoting heart health and helping boost immunity. To respond to this topic, in this work, uncoated nanoliposomes loaded with vitamin D3 and K2 were successfully prepared, by using a novel, high-yield and semi continuous technique based on simil-microfluidic principles. By the same technique, to promote and to enhance mucoadhesiveness and stability of the produced liposomal structures, chitosan was tested as covering material. By this way polymer–lipid hybrid nanoparticles, encapsulating vitamin D3 and vitamin K2, with improved features in terms of stability, loading and mucoadhesiveness were produced for potential nutraceutical and pharmaceutical applications.

Graphical abstract: Micronutrients encapsulation in enhanced nanoliposomal carriers by a novel preparative technology

Article information

Article type
Paper
Submitted
23 Apr 2019
Accepted
14 Jun 2019
First published
25 Jun 2019
This article is Open Access
Creative Commons BY license

RSC Adv., 2019,9, 19800-19812

Micronutrients encapsulation in enhanced nanoliposomal carriers by a novel preparative technology

A. Dalmoro, S. Bochicchio, G. Lamberti, P. Bertoncin, B. Janssens and A. A. Barba, RSC Adv., 2019, 9, 19800 DOI: 10.1039/C9RA03022K

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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