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Issue 34, 2019, Issue in Progress
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Supramolecular gels from sugar-linked triazole amphiphiles for drug entrapment and release for topical application

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Abstract

A simple molecular framework obtained by cross-linking a hydrophobic chain with S,S- and R,R-tetritol by the copper-catalysed azide–alkyne cycloaddition reaction is found to serve as an excellent bioisostere for self-assembly. The hexadecyl-linked triazolyl tetritol composite spontaneously self-assembles in n-hepane and methanol to form hierarchical organogels. Microscopic analyses and X-ray diffraction studies demonstrate eventual formation of nanotubes through lamellar assembly of the amphiphiles. A rheological investigation shows solvent-dictated mechanical properties that obey power law behavior similar to other low molecular weight gelators (LMOGs). The gel network was then utilized for the entrapment of drugs e.g. ibuprofen and 5-fluorouracil, with tunable mechanical behaviour under applied stress. The differential release profiles of the drugs over a period of a few hours as a result of the relative spatio-temporal location in the supramolecular network can be utilized for topical formulations.

Graphical abstract: Supramolecular gels from sugar-linked triazole amphiphiles for drug entrapment and release for topical application

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Supplementary files

Article information


Submitted
16 Apr 2019
Accepted
14 Jun 2019
First published
27 Jun 2019

This article is Open Access

RSC Adv., 2019,9, 19819-19827
Article type
Paper

Supramolecular gels from sugar-linked triazole amphiphiles for drug entrapment and release for topical application

K. Sharma, J. P. Joseph, A. Sahu, N. Yadav, M. Tyagi, A. Singh, A. Pal and K. P. R. Kartha, RSC Adv., 2019, 9, 19819
DOI: 10.1039/C9RA02868D

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